Walchner M, Leib-Mösch C, Messer G, Germaier H, Plewig G, Kind P
Department of Dermatology, Ludwig-Maximilians-Universität, München, Germany.
Arch Dermatol. 1997 Jun;133(6):767-71.
To update information on endogenous retroviral sequences and discuss their role in systemic autoimmune disease.
Articles retrieved after MEDLINE search and personal communications and cooperation with the Institute of Virology.
There are 2 modes of pathogenetic mechanisms through which endogenous retroviral sequences could cause systemic autoimmune disease: expression of endogenous retroviral gene products sharing antigenic determinants with cellular proteins; and activation or destruction of cellular genes as a consequence of insertional mutagenesis. Both mechanisms have been demonstrated in vitro and in vivo in animal models.
Investigations on endogenous retroviral sequences in humans may offer new insights into the pathogenesis of autoimmune disease.
更新关于内源性逆转录病毒序列的信息，并探讨它们在系统性自身免疫性疾病中的作用。
通过医学文献数据库检索以及个人交流和与病毒学研究所合作获取的文章。
内源性逆转录病毒序列可能通过两种致病机制导致系统性自身免疫性疾病：内源性逆转录病毒基因产物与细胞蛋白共享抗原决定簇；插入诱变导致细胞基因激活或破坏。这两种机制均已在动物模型的体内和体外得到证实。
对人类内源性逆转录病毒序列的研究可能为自身免疫性疾病的发病机制提供新的见解。
