Zekraoui L, Lagarde J P, Raisonnier A, Gérard N, Aouizérate A, Lucotte G
Laboratory of Molecular Genetics, CHU Pitié-Salpêtrière, Paris, France.
Hum Biol. 1997 Aug;69(4):575-81.
Apolipoprotein E genotypes (alleles 2, 3, and 4) have been determined in 70 Aka Pygmies and 470 unrelated African sub-Saharan subjects. Allele frequencies for Pygmies are 5.7% for APOE2, 53.6% for APOE3, and 40.7% for APOE4, and the global proportions for sub-Saharan subjects are 11.6% for APOE2, 70.6% for APOE3, and 17.8% for APOE4. The frequencies in some ethnic groups are statistically different from the overall mean in the Afar and the Isa, the Ewe (Togo), the Malinke (Guinea), and the Mossi; three ethnic groups have a higher allele frequency of APOE4 (Fon, 29.4%; Zairians, 33.3%; Tutsi, 38.5%). The APOE*4 allele is considered the ancestral form because of its high frequency in African Pygmies and other aboriginal populations.
已对70名阿卡俾格米人和470名撒哈拉以南非洲地区无亲缘关系的受试者进行了载脂蛋白E基因型（等位基因2、3和4）测定。俾格米人的等位基因频率为：APOE2为5.7%，APOE3为53.6%，APOE4为40.7%；撒哈拉以南地区受试者的总体比例为：APOE2为11.6%，APOE3为70.6%，APOE4为17.8%。在一些族群中，其频率与阿法尔人和伊萨人、埃维人（多哥）、马林凯人（几内亚）和莫西人的总体平均值在统计学上存在差异；有三个族群的APOE4等位基因频率较高（芳族，29.4%；扎伊尔人，33.3%；图西人，38.5%）。由于APOE*4等位基因在非洲俾格米人和其他原住民群体中的高频率，它被认为是原始形式。
