Sacha T, Skotnicki A B
Kliniki Hematologii, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 1997;54(2):122-5.
The effect of magnesium on coagulation system is still an interesting subject for investigations. Shionoya in his publication (1927) reported for the first time possible inhibitory effect of magnesium on coagulation system. Since then, a large number of studies were undertaken to explain the mechanisms of influence of Mg++ on plasma coagulation, platelet function and fibrinolysis. In recent decades, the effect of magnesium on coagulation has led to controversy in a wide range of scientific publications. At present, series of experiments are undertaken in laboratories using modern methodology to evaluate the possible effect of magnesium on coagulation. The results of Anders's and Frisch's study reported here support the theory of the authors, who found no change in coagulation in the presence of physiological concentration of magnesium in blood serum. The influence on the final results, often contradictory, could have: different type of study (in vitro or in vivo), the object of the study (human being, animal), concentrations of magnesium (in most of cases non-physiologic and toxic) and out of date methodology. In majority of reported here studies there were no control groups, and clinical trials were not a double blind studies.
镁对凝血系统的影响仍是一个有趣的研究课题。盐谷在其1927年发表的文章中首次报道了镁对凝血系统可能存在的抑制作用。从那时起，人们进行了大量研究以解释Mg++对血浆凝血、血小板功能和纤维蛋白溶解的影响机制。近几十年来，镁对凝血的影响在众多科学出版物中引发了争议。目前，实验室正在采用现代方法进行一系列实验，以评估镁对凝血的可能影响。此处报道的安德斯和弗里施的研究结果支持了作者的理论，即他们发现在血清中镁的生理浓度下凝血没有变化。对最终结果的影响往往相互矛盾，其可能原因有：不同类型的研究（体外或体内）、研究对象（人类、动物）、镁的浓度（大多数情况下是非生理和有毒的）以及过时的方法。在这里报道的大多数研究中没有对照组，而且临床试验也不是双盲研究。
