Fukunaga M, Ushigome S
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Arch Pathol Lab Med. 1997 Jun;121(6):599-603.
The histogenesis of myofibroblastoma of the breast remains unknown.
Two cases of myofibroblastoma of the female breast were analyzed using light microscopy and immunohistochemistry.
The tumors were well circumscribed and predominantly composed of bland bipolar spindle cells and interspersed bands of hyalinized collagen. Additionally, one tumor contained a cartilaginous island, and the other contained a well-defined small nodule that consisted of fascicular arrangements of mitotically inactive atypical cells, simulating atypical leiomyoma. Both lesions contained a fatty element. Immunohistochemically, spindle tumor cells expressed desmin, alpha-smooth muscle actin, muscle actin, and CD34. The atypical cells were strongly and diffusely positive for all these markers. Both tumors were DNA diploid and had a moderate S-phase fraction. The patients have no evidence of disease 4 and 18 months after simple excision.
Myofibroblastoma of the breast may be a benign mesenchymal neoplasm capable of diverse lines of differentiation.
乳腺肌纤维母细胞瘤的组织发生仍不清楚。
对两例女性乳腺肌纤维母细胞瘤进行了光镜和免疫组化分析。
肿瘤边界清晰，主要由温和的双极梭形细胞和散在的玻璃样变胶原带组成。此外，一个肿瘤含有一个软骨岛，另一个含有一个界限清楚的小结节，由有丝分裂不活跃的非典型细胞束状排列组成，类似非典型平滑肌瘤。两个病变均含有脂肪成分。免疫组化显示，梭形肿瘤细胞表达结蛋白、α-平滑肌肌动蛋白、肌动蛋白和CD34。非典型细胞对所有这些标志物均呈强阳性且弥漫性阳性。两个肿瘤均为DNA二倍体，S期比例适中。患者在单纯切除术后4个月和18个月无疾病证据。
乳腺肌纤维母细胞瘤可能是一种能够进行多种分化的良性间叶性肿瘤。
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