Lantin A, Maskens A, Michel L, Vandeperre J
Acta Chir Belg. 1977 Jul-Aug;76(4):445-52.
Breast cancer is a chronic disease, often generalized at the time of diagnosis. Present treatments are efficient only if the tumor is still localized so that results are relatively disappointing. Careful clinical appraisal will define the chances of a disabling treatment and the limits of a curative treatment. Systematic histologic study of axillary nodes completes the clinical examination, is a reliable measure of the risk of dissemination at the time of treatment and indicates the necessity for complementary chemotherapy. The main choices of treatment for initial stages are presented. Radical mastectomy, according to the literature appears best as it adds a precise diagnosis to a safe result. Mastectomy without resection of the pectoralis major is a cosmetic alternative with statistical and experimental soundness. Complementary prophylactic irradiation for radical mastectomy should be reserved for high risk of local recurrence and for control of metastases to the internal mammary nodes.
乳腺癌是一种慢性疾病，通常在诊断时已发生转移。目前的治疗方法只有在肿瘤仍局限时才有效，因此治疗结果相对令人失望。仔细的临床评估将确定致残性治疗的可能性和治愈性治疗的限度。对腋窝淋巴结进行系统的组织学研究可完善临床检查，是治疗时判断扩散风险的可靠指标，并提示辅助化疗的必要性。文中介绍了早期乳腺癌的主要治疗选择。根据文献，根治性乳房切除术似乎是最佳选择，因为它能在确保安全的同时提供精确诊断。保留胸大肌的乳房切除术是一种具有统计学和实验依据的美容替代方案。根治性乳房切除术的辅助预防性放疗应仅用于局部复发高风险患者以及控制内乳淋巴结转移。
