Herget J, Pelouch V, Kolár F, Ostádal B
Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Physiol Res. 1996;45(3):221-6.
The effect of chronic administration of angiotensin converting enzyme inhibitor on the development of hypoxic pulmonary hypertension was studied in rats. Male Wistar rats were-exposed for 3 weeks to isobaric hypoxia (10% O2) and treated with 10 mg/kg b.w. of Ramipril daily. The haemodynamic properties of the pulmonary vasculature were then measured in isolated blood-perfused lung preparation. Ramipril administration during the sojourn in hypoxia resulted in lower baseline perfusion pressure and lower slope of perfusion pressure-flow relationship compared to non-treated hypoxic rats. Partitioning of the distribution of pulmonary vascular resistance across the vascular bed by the occlusion technique showed that it was mainly due to a decrease of arterial and venous vascular resistances to blood flow. It is suggested that Ramipril attenuates the process of morphological reconstruction of pulmonary vasculature by chronic hypoxia rather than the level of vascular smooth muscle tone.
在大鼠中研究了长期给予血管紧张素转换酶抑制剂对缺氧性肺动脉高压发展的影响。将雄性Wistar大鼠暴露于等压缺氧环境（10%氧气）3周，并每日给予10 mg/kg体重的雷米普利进行治疗。然后在离体血液灌注肺标本中测量肺血管系统的血流动力学特性。与未治疗的缺氧大鼠相比，在缺氧期间给予雷米普利导致较低的基础灌注压和较低的灌注压-流量关系斜率。通过闭塞技术对肺血管阻力在血管床中的分布进行划分显示，这主要是由于动脉和静脉对血流的血管阻力降低所致。提示雷米普利可减轻慢性缺氧引起的肺血管形态重建过程，而非血管平滑肌张力水平。
