Stellzig A, Basdra E K, Komposch G
Poliklinik für Kieferorthopädie, Klinik für Mund-, Zahn- und Kieferkrankheiten, Universität Heidelberg.
J Orofac Orthop. 1997;58(3):144-53. doi: 10.1007/BF02676545.
There are many publications in the literature focusing on clinical, radiological and surgical aspects of the treatment of mesiodentes. However, the etiology of this dental anomaly remains widely unclear. The purpose of this study was to evaluate etiologic factors for mesiodentes in a collective comprising 30 patients with a total of 45 mesiodentes. Thirty-one percent of the patients showed a familial disposition, pointing to inheritance as a key factor in the development of mesiodentes. Our results further support the hypothesis of related etiologic factors for several dental and craniofacial anomalies, such as hyperdontia, hypodontia and cleft lip and palate. Finally, we report the gemination of a deciduous incisor on the same side as a mesiodens. We also found differences in the mesiodistal width of central incisors depending on unilateral or bilateral occurrence of mesiodentes. Both these findings support the dichotomy theory of the split in the tooth bud inducing the development of mesiodentes, a theory we favor over that of local hyperactivity of the dental lamina.
文献中有许多出版物聚焦于正中多生牙治疗的临床、放射学和外科方面。然而，这种牙齿异常的病因仍广泛不明。本研究的目的是在一个包含30例患者共45颗正中多生牙的群体中评估正中多生牙的病因学因素。31%的患者表现出家族倾向，表明遗传是正中多生牙发生发展的关键因素。我们的结果进一步支持了几种牙齿和颅面异常（如多生牙、缺牙以及唇腭裂）相关病因学因素的假说。最后，我们报告了一颗乳牙切牙与一颗正中多生牙萌生于同一侧的双生牙情况。我们还发现，根据正中多生牙单侧或双侧出现情况，中切牙近远中宽度存在差异。这两个发现均支持牙蕾分裂诱导正中多生牙发育的二分理论，相较于牙板局部活跃理论，我们更倾向于这一理论。
