Suzuki Y, Yamamoto N
Department of Microbiology, Tokyo Medical and Dental University School of Medicine.
Nihon Rinsho. 1997 Jun;55(6):1563-71.
AIDS(acquired immunodeficiency syndrome) is caused by HIV(human immunodeficiency virus) that belongs to the lentivirus group. Generally, the length of time between HIV infection and development of AIDS is considered to be 10 years on average, but a few percent of infected persons-so-called long-term non progressor, do not develop AIDS even more than 10 years after infection. In long-term non progressors, it has been described that 1) there is a low viral load, 2) isolated HIV is relatively non virulent type, 3) antibody to HIV do not enhance virus propagation, 4) type 1 cytokines is more dominant than type 2, and 5) antiviral activity of CD8+ cell is strong. Thus, in long-term non progressors, the immune-response actively suppress HIV proliferation, so that viruses are controlled at low level.
获得性免疫缺陷综合征（AIDS）由属于慢病毒组的人类免疫缺陷病毒（HIV）引起。一般来说，从感染HIV到发展为AIDS的时间长度平均被认为是10年，但有百分之几的感染者——即所谓的长期不进展者，即使在感染10年以上也不会发展为AIDS。在长期不进展者中，有如下描述：1）病毒载量低；2）分离出的HIV相对为低毒力类型；3）抗HIV抗体不会增强病毒增殖；4）1型细胞因子比2型更占主导；5）CD8 +细胞的抗病毒活性强。因此，在长期不进展者中，免疫反应会积极抑制HIV增殖，从而将病毒控制在低水平。
