del Rosario M L, Saleh A
Division of Pediatric Hematology/Oncology, University of Florida Health Science Center, Gainesville, USA.
J Pediatr Hematol Oncol. 1997 May-Jun;19(3):247-50. doi: 10.1097/00043426-199705000-00013.
Malignant hemangiopericytoma is an uncommon tumor in the pediatric age group. A case of congenital hemangiopericytoma is presented with a review of the literature.
A 2-month-old boy presented at birth with an enlarging posterior neck mass. Subsequent histopathologic studies showed findings consistent with hemangiopericytoma. Imaging studies demonstrated an extensive, infiltrative, vascular lesion not readily amenable to surgical resection. A pulmonary metastatic lesion was present.
Combined treatment using vincristine, doxorubicin, and cyclophosphamide given preoperatively resulted in a significant decrease in size of the primary tumor, allowing for resection without complication and resolution of the metastatic lesion.
Preoperative chemotherapy may have a significant role in the management of infants with malignant hemangiopericytoma.
恶性血管外皮细胞瘤在儿童年龄组中是一种罕见肿瘤。本文报告1例先天性血管外皮细胞瘤病例并复习相关文献。
一名2个月大男婴出生时即发现后颈部肿物不断增大。随后的组织病理学研究显示结果符合血管外皮细胞瘤。影像学检查显示为广泛、浸润性的血管病变，难以通过手术切除。存在肺部转移病灶。
术前使用长春新碱、阿霉素和环磷酰胺联合治疗使原发肿瘤体积显著减小，得以顺利切除且无并发症，转移病灶也消失。
术前化疗在恶性血管外皮细胞瘤婴儿的治疗中可能发挥重要作用。
