Calabresi P, Pisani A, Centonze D, Bernardi G
Clinical Neurologica, Dip. Sanità, Università di Roma Tor Vergata, Italy.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1997 Apr;17(2):101-4.
Several studies have tried to clarify the role of different dopamine (DA) receptors in the control of membrane excitability of striatal neurons. Activation of DA receptors influences both synaptic and intrinsic membrane properties of striatal neurons. More recently it has been reported that endogenous DA plays an important role in the expression of striatal synaptic plasticity. In this review we will try to summarize and discuss the available data concerning the possible impact of the functional role of D1 and D2 receptor activation on the short- and long-term modulation of the excitatory glutamatergic corticostriatal transmission. Moreover, we will also describe the function of the striatum in the integration of glutamatergic and DAergic inputs to produce long-term changes of synaptic efficacy: long-term depression (LTD) and long-term potentiation (LTP).
多项研究试图阐明不同多巴胺（DA）受体在控制纹状体神经元膜兴奋性中的作用。DA受体的激活会影响纹状体神经元的突触和内在膜特性。最近有报道称，内源性DA在纹状体突触可塑性的表达中起重要作用。在本综述中，我们将试图总结和讨论现有数据，这些数据涉及D1和D2受体激活的功能作用对兴奋性谷氨酸能皮质纹状体传递的短期和长期调节可能产生的影响。此外，我们还将描述纹状体在整合谷氨酸能和多巴胺能输入以产生突触效能的长期变化（长期抑制，即LTD和长期增强，即LTP）中的功能。
