Bajema I M, Hagen E C, Weverling-Rijnsburger A W, van der Pijl H, van Dorp W T, van Ravenswaay Claasen H H, Bruijn J A
Department of Pathology, Leiden University, The Netherlands.
Clin Nephrol. 1997 Jun;47(6):401-6.
Two cases of cerebral involvement in Wegener's granulomatosis (WG) are described. The course of the disease in both patients was characterized by sudden onset and fatal outcome, despite maximum immunosuppressive therapy. Cerebral involvement is a rare complication of WG. Over the past two decades, only a small number of case-reports appeared of patients with WG who showed this complication. Since the era of cyclophosphamide therapy, it is commonly assumed that cerebral involvement in WG has no influence on patient survival. However, the two patients described here both died shortly after the occurrence of central neurological symptoms.
本文描述了两例韦格纳肉芽肿（WG）累及脑部的病例。尽管进行了最大程度的免疫抑制治疗，但两名患者的病程均以突然起病和致命结局为特征。脑部受累是WG的一种罕见并发症。在过去二十年中，仅有少量关于出现这种并发症的WG患者的病例报告。自环磷酰胺治疗时代以来，人们普遍认为WG累及脑部对患者生存没有影响。然而，此处描述的两名患者在出现中枢神经症状后不久均死亡。
