Bandyopadhyay B C, Poddar M K
Department of Biochemistry, University College of Science, University of Calcutta, India.
Methods Find Exp Clin Pharmacol. 1997 Apr;19(3):181-4.
Theophylline at low doses (10 mg/kg/day p.o.) under long-term conditions (for 16 consecutive days) increased the adenosine deaminase (ADA) activity in spleen and thymus of adult male albino rats without changing its hepatic ADA activity. Treatment with high doses (20 mg/kg/day p.o.) under similar conditions, on the other hand, decreased the splenic and hepatic ADA activity and increased the thymic ADA activity. This induction of thymic ADA activity, however, was significantly less than that observed with low doses of theophylline. The plasma corticosterone level was increased without changing its adrenal level under similar conditions. This study, thus, indicates that long-term theophylline treatment may potentiate or suppress the immune response, depending on the dose, through the tissue (liver/spleen/thymus)-specific modulation of ADA activity and plasma corticosterone status.
长期（连续16天）给予低剂量（口服10毫克/千克/天）的茶碱可增加成年雄性白化大鼠脾脏和胸腺中的腺苷脱氨酶（ADA）活性，而肝脏中的ADA活性未发生变化。另一方面，在类似条件下给予高剂量（口服20毫克/千克/天）的茶碱，则会降低脾脏和肝脏中的ADA活性，并增加胸腺中的ADA活性。然而，这种对胸腺ADA活性的诱导作用明显低于低剂量茶碱所观察到的效果。在类似条件下，血浆皮质酮水平升高，而肾上腺水平未发生变化。因此，这项研究表明，长期使用茶碱治疗可能会根据剂量通过组织（肝脏/脾脏/胸腺）特异性调节ADA活性和血浆皮质酮状态来增强或抑制免疫反应。
