Kilpatrick C, Murrie V, Cook M, Andrewes D, Desmond P, Hopper J
Department of Neurology, Melbourne Neuroscience Centre, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Seizure. 1997 Jun;6(3):213-8. doi: 10.1016/s1059-1311(97)80008-8.
The relationship between the degree and distribution of hippocampal atrophy measured by volumetric magnetic resonance imaging and severity of memory deficits in 25 patients with temporal lobe epilepsy secondary to mesial temporal sclerosis was assessed. Hippocampal volumes were expressed as a ratio of smaller to larger, normal ratio greater than 0.95. Neuropsychology tests included: subtests of the WAIS-R, Rey Auditory Verbal Learning Task, Rey Figure and the Austin Maze. Degree of left hippocampal atrophy in patients with left temporal lobe epilepsy was associated with severity of verbal memory deficits as measured by RAVLT total recall (P < 0.05), delayed recall (P < 0.001), story recognition (P < 0.001), list recognition (P < 0.001) and final delayed recall (P < 0.001) and recall of the Rey Figure (P < 0.01). There was no association between degree of right hippocampal atrophy and any of the memory tests. Diffuse left hippocampal atrophy was associated with more severe verbal memory deficits than anterior atrophy. We conclude, the association between degree of left hippocampal atrophy and verbal memory provides further evidence of the predominant involvement of the left hippocampus in verbal memory. The finding of a relationship between degree of left hippocampal atrophy and measures of non-verbal function suggests these tests are dependent on verbal memory, or that mesial temporal sclerosis is a bilateral but asymmetrical condition.
评估了25例内侧颞叶硬化继发颞叶癫痫患者通过容积磁共振成像测量的海马萎缩程度和分布与记忆缺陷严重程度之间的关系。海马体积以较小与较大体积的比值表示，正常比值大于0.95。神经心理学测试包括：韦氏成人智力量表修订版（WAIS-R）的分测验、雷伊听觉词语学习任务、雷伊图形测验和奥斯汀迷宫测验。左侧颞叶癫痫患者左侧海马萎缩程度与雷伊听觉词语学习任务总回忆（P<0.05）、延迟回忆（P<0.001）、故事识别（P<0.001）、列表识别（P<0.001）、最终延迟回忆（P<0.001）以及雷伊图形回忆（P<0.01）所测量的言语记忆缺陷严重程度相关。右侧海马萎缩程度与任何记忆测试均无关联。弥漫性左侧海马萎缩比前部萎缩与更严重的言语记忆缺陷相关。我们得出结论，左侧海马萎缩程度与言语记忆之间的关联进一步证明了左侧海马在言语记忆中占主导地位。左侧海马萎缩程度与非言语功能测量之间存在关系这一发现表明，这些测试依赖于言语记忆，或者内侧颞叶硬化是一种双侧但不对称的疾病。
