Wong B, Choi Y
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 295, New York, NY 10021, USA.
Curr Opin Immunol. 1997 Jun;9(3):358-64. doi: 10.1016/s0952-7915(97)80082-9.
Antigen-induced apoptosis of T cells is a highly regulated process which plays a key role in the elimination of self-reactive T cells and, thus, in the prevention of autoimmunity. It has recently become apparent that members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily regulate antigen-induced T-cell death. Studies characterizing genes which control TNF/TNFR superfamily expression and how TNF/TNFR signal transducers activate cell death machinery, such as caspases, have begun to reveal the molecular control of antigen-induced T-cell death.
抗原诱导的T细胞凋亡是一个高度调控的过程，在清除自身反应性T细胞从而预防自身免疫方面发挥关键作用。最近已明确，肿瘤坏死因子（TNF）和TNF受体（TNFR）超家族的成员可调节抗原诱导的T细胞死亡。关于控制TNF/TNFR超家族表达的基因以及TNF/TNFR信号转导分子如何激活细胞死亡机制（如半胱天冬酶）的研究，已开始揭示抗原诱导的T细胞死亡的分子调控机制。
