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非胰岛素依赖型糖尿病患者糖化白蛋白升高是近期日常环境应激的一种表现。

Elevated glycosylated albumin in NIDDM is a function of recent everyday environmental stress.

作者信息

Aikens J E, Mayes R

机构信息

Department of Psychiatry, University of Chicago, Illinois 60637-1470, USA.

出版信息

Diabetes Care. 1997 Jul;20(7):1111-3. doi: 10.2337/diacare.20.7.1111.

DOI:10.2337/diacare.20.7.1111
PMID:9203446
Abstract

OBJECTIVE

To evaluate the association of recent daily environmental stress (daily hassles) with glycemia in NIDDM.

RESEARCH DESIGN AND METHODS

Fifty-five NIDDM patients reported the number and intensity of daily hassles occurring during the past week and concurrently underwent glycemic assessment.

RESULTS

Hassles were generally unassociated with demographic variables, illness duration, treatment regimen, and the presence of complications. Multiple regression analysis indicated that hassles (in both frequency and intensity) were positively associated with recent glycemia (glycosylated albumin [GA]), even after statistically controlling for long-term glycemia (glycosylated hemoglobin [HbA(1c)]). The subtypes of hassles having the most potent relationships with GA were work and family/friend-related stressors.

CONCLUSIONS

The frequency and perceived impact of everyday minor stress have proximal positive associations with glycemia that do not necessarily reflect chronic hyperglycemia. Stress arising from work and family/friend sources may be particularly relevant.

摘要

目的

评估近期日常环境压力(日常烦心事)与非胰岛素依赖型糖尿病(NIDDM)患者血糖之间的关联。

研究设计与方法

55例NIDDM患者报告了过去一周内发生的日常烦心事的数量和强度,并同时接受了血糖评估。

结果

烦心事通常与人口统计学变量、病程、治疗方案及并发症的存在无关。多元回归分析表明,即使在对长期血糖(糖化血红蛋白[HbA(1c)])进行统计学控制后,烦心事(频率和强度)与近期血糖(糖化白蛋白[GA])仍呈正相关。与GA关系最密切的烦心事亚型是工作及与家人/朋友相关的压力源。

结论

日常轻微压力的频率和感知影响与血糖呈近端正相关,这不一定反映慢性高血糖。工作以及家庭/朋友方面产生的压力可能尤为相关。

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