Torchilin V P
Center for Imaging and Pharmaceutical Research, Massachusetts General Hospital, Charlestown, USA.
Q J Nucl Med. 1997 Jun;41(2):141-53.
The current status of application of liposomes and micelles as carriers for diagnostic imaging agents in experimental and clinical medicine is considered. Liposomes and micelles loaded with appropriate contrast agents have been shown to be suitable for all imaging modalities, including gamma-, magnetic resonance (MR), and computed tomography (CT). The methods are briefly described to prepare liposomes loaded with various contrast agents, as well as some basic data on their in vitro and in vivo properties and biodistribution. Certain pharmacokinetic considerations associated with the use of plain and long-circulating liposomes and micelles as pharmaceutical carriers are discussed. The application of contrast-loaded liposomes in different modalities for the experimental and clinical imaging of various organs, tissues, and pathological conditions is briefly reviewed. New trends in the preparation and use of contrast-loaded liposomes and micelles are also considered, such as the application of amphiphilic polychelating polymers and polymers for steric protection of microparticulate pharmaceutical carriers.
本文探讨了脂质体和胶束作为实验医学和临床医学中诊断成像剂载体的应用现状。已证明，装载适当造影剂的脂质体和胶束适用于所有成像方式，包括γ射线、磁共振（MR）和计算机断层扫描（CT）。简要描述了制备装载各种造影剂的脂质体的方法，以及它们的体外和体内性质及生物分布的一些基础数据。讨论了与使用普通和长循环脂质体及胶束作为药物载体相关的某些药代动力学考虑因素。简要综述了装载造影剂的脂质体在不同成像方式中对各种器官、组织和病理状况进行实验和临床成像的应用。还考虑了装载造影剂的脂质体和胶束制备及使用方面的新趋势，例如两亲性聚螯合聚合物和用于微粒药物载体空间保护的聚合物的应用。
