Zoppellari R, Borron S W, Chieregato A, Targa L, Scaroni I, Zatelli R
1 Servizio di Anestesia e Rianimazione, Azienda Ospedaliera Arcispedale S. Anna, Ferrara, Italy.
J Toxicol Clin Toxicol. 1997;35(4):401-4. doi: 10.3109/15563659709043373.
We report a unique case of attempted suicide by intramuscular injection of the organophosphate isofenphos which resulted in a muscarinic and nicotinic syndrome lasting 15 days and requiring prolonged mechanical ventilation and hospitalization. The patient, who demonstrated no signs of delayed polyneuropathy on hospital day 25, subsequently died of pneumonia. Toxicological investigations showed isofenphos plasma decay and confirmed the intramuscular route of poisoning. We believe continuous isofenphos absorption resulted in the prolonged intoxication observed in this patient.
我们报告了一例独特的自杀未遂案例，患者通过肌肉注射有机磷酸酯类农药异柳磷企图自杀，导致出现持续15天的毒蕈碱样和烟碱样综合征，需要长时间机械通气和住院治疗。该患者在住院第25天时未表现出迟发性多发性神经病的迹象，随后死于肺炎。毒理学调查显示异柳磷在血浆中的衰减情况，并证实了中毒途径为肌肉注射。我们认为，异柳磷的持续吸收导致了该患者出现长时间中毒症状。
