核糖体和核糖体RNA的构象。

The conformation of ribosomes and rRNA.

作者信息

Moore P B

机构信息

Department of Chemistry, Yale University, New Haven, CT 06511, USA.

出版信息

Curr Opin Struct Biol. 1997 Jun;7(3):343-7. doi: 10.1016/s0959-440x(97)80049-8.

DOI:10.1016/s0959-440x(97)80049-8

PMID:9204275

Abstract

During the past 18 months, electron microscopists have published two reconstructions of the Escherichia coli ribosome, independently derived from images of unstained particles. The resolutions of their images are 20-25 A-much higher than any previously available. During the same time, NMR spectroscopists have provided an atomic-resolution model for the A-site region of 16S rRNA complexed with paromomycin that explains much of what is known about the interaction of aminoglycoside antibiotics with ribosomes.

摘要

在过去的18个月里，电子显微镜学家发表了两篇对大肠杆菌核糖体的重构，它们独立来源于未染色颗粒的图像。其图像分辨率为20 - 25埃，比之前任何可用的分辨率都要高得多。与此同时，核磁共振光谱学家为与巴龙霉素复合的16S rRNA的A位点区域提供了一个原子分辨率模型，该模型解释了许多关于氨基糖苷类抗生素与核糖体相互作用的已知情况。