在灵长目、啮齿目和兔形目动物基因组中鉴定新的中等重复频率重复序列。
Identification of new medium reiteration frequency repeats in the genomes of Primates, Rodentia and Lagomorpha.
作者信息
Jurka J, Kapitonov V V, Klonowski P, Walichiewicz J, Smit A F
机构信息
Genetic Information Research Institute, Palo Alto, CA 94306, USA.
出版信息
Genetica. 1996;98(3):235-47. doi: 10.1007/BF00057588.
We report eleven new families of MEdium Reiteration frequency (MER) interspersed repeats in the genomes of Primates, Rodentia, and Lagomorpha. Two families of the human repeats, MER 46 and MER 47, represent non-autonomous DNA transposons. These sequences are flanked by TA target site duplications and have terminal inverted repeats (TIRs) similar to TIRs of DNA transposons. The sequences of five other families of repeats, MER41, MER48, MER50, MER51, and RMER3, resemble long terminal repeats of retroviruses. A potential involvement of some of the reported MER repeats in the regulation of transcription and genetic rearrangements is suggested. Age estimations place the origin of most MER repeats at the time of decline in MIR (Mammalian-wide Interspersed Repeats) retroposition and before the origin of the Alu family.
我们报告了灵长目、啮齿目和兔形目基因组中11个新的中度重复频率（MER）散在重复序列家族。人类重复序列中的两个家族，MER 46和MER 47，代表非自主DNA转座子。这些序列两侧是TA靶位点重复序列，并且具有与DNA转座子的末端反向重复序列（TIR）相似的末端反向重复序列。其他五个重复序列家族，MER41、MER48、MER50、MER51和RMER3的序列类似于逆转录病毒的长末端重复序列。提示了一些已报道的MER重复序列可能参与转录调控和基因重排。年代估计表明，大多数MER重复序列起源于MIR（全哺乳动物散在重复序列）逆转录插入减少之时，且早于Alu家族的起源。
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