Royaux I, Bernier B, Montgomery J C, Flaherty L, Goffinet A M
Department of Physiology, FUNDP Medical School, Namur, Belgium.
Genomics. 1997 Jun 15;42(3):479-82. doi: 10.1006/geno.1997.4772.
The reeler Albany2 mutation (Reln(rl-Alb2) in the mouse is an allele of reeler isolated during a chlorambucil mutagenesis screen. Homozygous animals had drastically reduced concentrations of reelin mRNA, in which an 85-nt exon was absent. At the genomic level, the mutation was shown to be due to an intracisternal A-particle insertion leading to exon skipping. This appears to be the first observation of retrotransposon insertion during chlorambucil mutagenesis.
