Charfi M R, Zbiba M, Belaljia M S, Lockhart A
Unité de Pneumologie, Hôpital des Forces de Sécurité Intérieure, La Marsa, Tunisie.
Rev Pneumol Clin. 1997;53(2):71-8.
The electrolytes and water transport across the respiratory epithelium have aroused particular interest for 20 years ago, with regard to the essential role they play in the regulation of the bronchial mucus composition and volume. The development of new in vitro and in vivo, techniques, allow better knowledge of these transport systems and their regulation. Transport involves two main ionic movements: chloride secretion and sodium absorption by the epithelial cells, associated with parallel water movements. In cystic fibrosis, the modification of bronchial mucus results from a defective protein-kinase dependent regulation of chloride secretion. This defect blocks water and chloride secretion by the respiratory epithelium causing dehydration of the mucus.
20年前，电解质和水在呼吸道上皮的转运就引起了特别关注，因为它们在调节支气管黏液的组成和体积方面发挥着重要作用。新的体外和体内技术的发展，使人们能更好地了解这些转运系统及其调节机制。转运主要涉及两种离子运动：上皮细胞的氯离子分泌和钠离子吸收，并伴有平行的水运动。在囊性纤维化中，支气管黏液的改变源于蛋白激酶依赖性氯离子分泌调节缺陷。这种缺陷阻碍了呼吸道上皮细胞的水和氯离子分泌，导致黏液脱水。
