Huang Z, Dai Q, Jiang T, Li J
Neurosurgery Institute, Harbin Medical University.
Chin Med J (Engl). 1996 Aug;109(8):626-30.
To evaluate the embolization effects and the long-term histologic changes, including the ultrastructure of the neoendothelium, in experimental canine aneurysms obliterated with self-made tungsten microcoil.
Twenty-eight experimental aneurysms were microsurgically created in 14 mongrel dogs by using end-to-side jungular carotid anastomosis. The aneurysms were obliterated with either self-made tungsten microcoil alone or the microcoil plus micro direct current electrocoagulation, with preservation of the parent vessel. The animals were kept in observation. 48 hours, 4 weeks, and 4 months after the embolization of the aneurysms, repeated carotid arteriography was performed to assess the potential recanalization of the aneurysms. The animals were then respectively killed and submitted for autopsy. The carotid artery and the embolized aneurysms were resected and studied with light and electron microscopy.
A total of 14 obliterated aneurysms were completely excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the microcoils with very minimal inflammatory reaction.
Tungsten microcoils are a relatively ideal embolic material at present for endovascular treatment of aneurysms. Microcoils plus micro direct current electrocoagulation yield more reliable, accurate, and safer embolic effects than microcoils alone for the obliteration of aneurysms.
评估用自制钨微线圈闭塞实验犬动脉瘤的栓塞效果及长期组织学变化，包括新生内皮的超微结构。
通过颈外动脉与颈内动脉端侧吻合，在14只杂种犬身上显微外科构建28个实验性动脉瘤。动脉瘤分别单用自制钨微线圈或微线圈加微直流电电凝进行闭塞，同时保留载瘤血管。对动物进行观察。在动脉瘤栓塞后48小时、4周和4个月，重复进行颈动脉血管造影，以评估动脉瘤的潜在再通情况。然后分别处死动物并进行尸检。切除颈动脉和栓塞的动脉瘤，进行光镜和电镜研究。
共有14个闭塞的动脉瘤被结缔组织内皮化层完全排除在体循环之外。动脉瘤底部被围绕微线圈的大量反应性纤维组织完全闭塞，炎症反应非常轻微。
钨微线圈是目前血管内治疗动脉瘤相对理想的栓塞材料。与单用微线圈闭塞动脉瘤相比，微线圈加微直流电电凝产生的栓塞效果更可靠、准确和安全。
