胰岛素依赖型糖尿病发病年龄相关的HLA - DQA1基因异质性
Age-of-onset related HLA-DQA1 genetic heterogeneity of insulin-dependent diabetes mellitus.
作者信息
Cheng H, Zhang Y, Fu Z, Yan T
机构信息
Department of Endocrinology, Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou.
出版信息
Chin Med J (Engl). 1996 Jun;109(6):474-7.
OBJECTIVE
To clarify whether there is an association of insulin-dependent diabetes mellitus (IDDM) susceptibility with HLA-DQA1 locus in adult-onset IDDM.
PATIENTS AND METHODS
Possible heterogeneity in immunogenetic aspects was investigated by comparing the findings on relationship between HLA-DQA1 52 Arg(+) and IDDM predisposition in three groups with different ages of IDDM onset (group A 14 years, group B 15-30 years, group C > 31 years).
RESULTS
The frequency of HLA-DQA1 52 Arg(+) in group A (87.5%) was higher than that in control (53.9%, P < 0.05) and in group B and C (P < 0.05). The frequency of HLA-DQA1 52 Arg(+)/Arg(+) phenotype in group A (75%) was higher than that in group C (23.1%, P < 0.05).
CONCLUSION
The contribution of HLA-DQA1 52 arginine to IDDM susceptibility is heterogeneous. Further study is necessary to clarify the immunogenetic entity of IDDM.
目的
明确成人起病的胰岛素依赖型糖尿病（IDDM）易感性与HLA - DQA1基因座之间是否存在关联。
患者与方法
通过比较三组不同发病年龄的IDDM患者（A组14岁，B组15 - 30岁，C组> 31岁）中HLA - DQA1 52 Arg(+)与IDDM易感性之间关系的研究结果，调查免疫遗传学方面可能存在的异质性。
结果
A组中HLA - DQA1 52 Arg(+)的频率（87.5%）高于对照组（53.9%，P < 0.05）以及B组和C组（P < 0.05）。A组中HLA - DQA1 52 Arg(+)/Arg(+)表型的频率（75%）高于C组（23.1%，P < 0.05）。
结论
HLA - DQA1 52精氨酸对IDDM易感性的影响存在异质性。有必要进一步研究以阐明IDDM的免疫遗传本质。
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