Lavelle C L
Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.
Endod Dent Traumatol. 1996 Oct;12(5):209-14. doi: 10.1111/j.1600-9657.1996.tb00517.x.
The stable prevalence of infective endocarditis since the advent of antibiotic prophylaxis for patients at-risk reflects the increasing polymicrobial etiology of such infections not associated with dental procedures. In addition to concerns for the growing crisis for antibiotic-resistant bacteria, the need for controlled clinical trials to determine the continued efficacy of prophylactic regimens for endodontic and other dental procedures cannot be overstated.
自从对高危患者采用抗生素预防措施以来，感染性心内膜炎的稳定患病率反映出此类感染（与牙科手术无关）的微生物病因越来越复杂。除了对抗生素耐药菌日益严重的危机感到担忧外，开展对照临床试验以确定牙髓病及其他牙科手术预防方案的持续疗效的必要性再怎么强调也不为过。
