Sparmann M, Eisenschenk A, Eisenschenk C, Gosztonyi G
Immanuel-Krankenhaus Berlin-Wannsee, Schwerpunktklinik Rheumatologie Land Berlin.
Handchir Mikrochir Plast Chir. 1997 Mar;29(2):73-8.
An experimental investigation was performed to examine the influence of ACTH on the long-term results of muscle regeneration after nerve repair. Twenty albino-rabbits ("White Russians") served as the animal model. The epi-perineural neurorrhaphy of the fibular nerve was carried out under microscopic control with 11x0 sutures. A computer-supported light-microscopic analysis of representative muscle-fiber diameters was performed for detection of nerve regeneration on the effector muscle of the peroneal nerve, the anterior tibial muscle, after 3, 4, 5 1/2, 7, and 8 months. In addition, the nerves were examined by light microscopy using not only standard techniques but also surgical immunohistological staining techniques (APAAP). The acceleration of nerve regeneration already described in the literature was confirmed by our investigations. However, the results observed after eight months were similar, regardless of the ACTH dosage applied. Muscle regeneration was not influenced by the injection of ACTH. It therefore does not appear justifiable to clinically apply ACTH for improvement of nerve and muscle regeneration.
进行了一项实验研究，以检验促肾上腺皮质激素（ACTH）对神经修复后肌肉再生长期结果的影响。选用20只白化兔（“俄罗斯白兔”）作为动物模型。在显微镜控制下，使用11-0缝线进行腓总神经的神经外膜缝合。在术后3、4、5.5、7和8个月，对腓总神经的效应肌即胫骨前肌进行代表性肌纤维直径的计算机辅助光学显微镜分析，以检测神经再生情况。此外，不仅使用标准技术，还使用手术免疫组织化学染色技术（碱性磷酸酶抗碱性磷酸酶法）对神经进行光学显微镜检查。我们的研究证实了文献中已描述的神经再生加速情况。然而，无论应用何种剂量的ACTH，八个月后观察到的结果相似。肌肉再生不受ACTH注射的影响。因此，临床上应用ACTH来改善神经和肌肉再生似乎没有道理。
