Dell'Isola A, Di Rosa G, Catalano D
II Università degli Studi di Napoli.
Minerva Ginecol. 1997 Apr;49(4):165-72.
Essential thrombocythemia is a rare disease of unknown etiology characterized by an abnormal increase in the platelet count which cannot be explained by other identifiable causes such as malignancy, infection, chronic inflammatory diseases or other myeloproliferative disorders. It rarely affects people less than 50 years of age and may be associated with hemorrhagic or thrombotic tendencies. A care of pregnancy complicated by essential thrombocythemia treated with aspirin, antiaggregating agent, throughout pregnancy and with hydroxyurea, a platelet lowering drug is reported. Also examine are some pathogenetic and therapeutic aspects of the thrombotic tendency secondary to elevated platelet count in pregnancy.
原发性血小板增多症是一种病因不明的罕见疾病,其特征为血小板计数异常增加,且无法用其他可识别的原因解释,如恶性肿瘤、感染、慢性炎症性疾病或其他骨髓增殖性疾病。它很少影响50岁以下的人群,可能与出血或血栓形成倾向有关。本文报道了一例在整个孕期使用阿司匹林(抗聚集剂)及羟基脲(一种降低血小板的药物)治疗的原发性血小板增多症合并妊娠病例。同时还探讨了妊娠期间血小板计数升高继发血栓形成倾向的一些发病机制和治疗方面的问题。