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[原发性血小板增多症与妊娠]

[Essential thrombocythemia and pregnancy].

作者信息

Baleiras Carla, Silva Ana, Serrano Fátima

机构信息

Serviço de Medicina Materno-Fetal, Maternidade Dr. Alfredo da Costa, Lisboa.

出版信息

Acta Med Port. 2003 Mar-Apr;16(2):87-91.

Abstract

Essencial Thrombocytemia is a rare chronic myeloproliferative disease of unknown etiology, characterized by markedly elevated platelet production (> 600,000/ml). It is more frequent among women above 50 years of age and may be associated with hemorrhagic or thrombotic tendencies. The authors report a case of Essencial Thrombocytemia diagnosed after several consecutive spontaneous abortions. Some clinical aspects, complications, differential diagnosis and management of this condition in pregnancy are also reviewed. An individualized, multidisciplinar approach and the treatment with acetylsalicylic acid, associated with interferon-alfa if necessary, will be the best therapeutic options for these patients.

摘要

原发性血小板增多症是一种病因不明的罕见慢性骨髓增殖性疾病,其特征为血小板生成显著增加(>600,000/ml)。它在50岁以上女性中更为常见,可能与出血或血栓形成倾向有关。作者报告了一例在连续多次自然流产后诊断出的原发性血小板增多症病例。本文还回顾了该疾病在妊娠期的一些临床特征、并发症、鉴别诊断及处理。对于这些患者,个体化的多学科方法以及必要时联合干扰素-α使用阿司匹林进行治疗将是最佳治疗选择。

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