Criscuolo M, Migaldi M, Trentini G P
Dipartimento di Scienze Morfologiche e Medico Legali, Università di Modena.
Pathologica. 1996 Dec;88(6):500-5.
All mammary lesions diagnosed at the Institute of Pathological Anatomy of the University of Modena have been systematically filed since 1990 and reported in a bulletin, which is issued twice a year and delivered to health operators. So far, 5.188 cases of breast lesions, comprising 1.999 non-neoplastic pathologies, 1.040 benign tumors, 1.943 primary malignant neoplasms and 206 recurrences, have been filed. During the quinquennium 1990-1994, a progressive numerical reduction in diagnoses of non-neoplastic lesions coupled to an increase of benign tumors has been observed, whereas the number of primary malignant tumors has not changed. In particular, a statistically significant increase in diagnoses of carcinoma-in-situ and of fibrocystic disease associated with moderate-risk lesions (atypical hyperplasias) has been detected, whereas the number of cases of single fibrocystic disease has decreased. This reduction, however, is not significant. A slight increase of breast carcinomas smaller than 1 cm and 2 cm, coupled to a decrease of those exhibiting dimensions between 2 and 5 cm, has been found. The collection and systematic analysis of cases of mammary lesions appears to represent a useful tool to study the incidence of different breast pathologies in the general populations. It can also be viewed as a simple way to test the reliability of diagnostic methods used for selection of surgical cases.
自1990年以来，摩德纳大学病理解剖研究所诊断的所有乳腺病变均已系统归档，并在一份每年发布两次并分发给卫生工作者的公报中报告。到目前为止，已归档5188例乳腺病变，包括1999例非肿瘤性病变、1040例良性肿瘤、1943例原发性恶性肿瘤和206例复发病例。在1990 - 1994年的五年期间，观察到非肿瘤性病变诊断数量逐渐减少，同时良性肿瘤数量增加，而原发性恶性肿瘤的数量没有变化。特别是，原位癌和与中度风险病变（非典型增生）相关的纤维囊性疾病的诊断有统计学上的显著增加，而单纯纤维囊性疾病的病例数有所减少。然而，这种减少并不显著。发现小于1厘米和2厘米的乳腺癌略有增加，而直径在2至5厘米之间的乳腺癌有所减少。乳腺病变病例的收集和系统分析似乎是研究普通人群中不同乳腺疾病发病率的有用工具。它也可以被视为一种检验用于选择手术病例的诊断方法可靠性的简单方法。
