Woo K S, McCrohon J A, Chook P, Adams M R, Robinson J T, McCredie R J, Lam C W, Feng J Z, Celermajer D S
Department of Medicine, Chinese University of Hong Kong, Hong Kong.
J Am Coll Cardiol. 1997 Jul;30(1):113-8. doi: 10.1016/s0735-1097(97)00111-3.
We sought to assess the effects of aging on the endothelial physiology of a group of Chinese adults.
Several studies have documented an association between aging and progressive arterial endothelial dysfunction in white subjects. We hypothesized that age-related endothelial dysfunction, an important event in atherosclerosis, might be less marked in southern Chinese subjects, in whom the prevalence of coronary heart disease is only approximately 20% of that in industrialized countries.
We studied endothelial function in 76 healthy adults aged 16 to 70 years: 38 Chinese from a village of 3,000 people in southern China and 38 white subjects from Sydney, Australia. In each ethnic group, there were 19 younger persons (16 to 40 years) and 19 older adults (55 to 70 years). None had evidence of diabetes, hypertension or clinical vascular disease or had ever been regular cigarette smokers. With the use of high resolution external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (causing endothelium-dependent dilation) and after sublingual nitroglycerin (an endothelium-independent dilator).
Endothelium-dependent dilation was similar in young Chinese (mean +/- SD 8.3 +/- 2.5%), young whites (7.9 +/- 2.0%) and older Chinese (6.8 +/- 2.9%), but it was significantly impaired in older whites (1.8 +/- 2.5%, p < 0.001 by analysis of variance). On multivariate analysis, older age was associated with impaired endothelium-dependent dilation (p < 0.001) (independent of the effects of serum cholesterol, gender and vessel size) in the white but not in the Chinese subjects (p = 0.83). Nitroglycerin-induced dilation was not significantly different with aging in either ethnic group.
Endothelium-dependent dilation is similar in the arteries of healthy young Chinese and white adults. With older age, however, Chinese subjects are less susceptible to impaired endothelial function.
我们试图评估衰老对一组中国成年人内皮生理功能的影响。
多项研究记录了白人受试者中衰老与进行性动脉内皮功能障碍之间的关联。我们假设，与年龄相关的内皮功能障碍是动脉粥样硬化中的一个重要事件，在冠心病患病率仅为工业化国家约20%的中国南方人群中可能不那么明显。
我们研究了76名年龄在16至70岁之间的健康成年人的内皮功能：38名来自中国南方一个3000人的村庄的中国人，以及38名来自澳大利亚悉尼的白人。在每个种族群体中，有19名年轻人（16至40岁）和19名老年人（55至70岁）。没有人有糖尿病、高血压或临床血管疾病的证据，也从未有规律地吸烟。通过使用高分辨率外部血管超声，在静息状态下、血流增加后（引起内皮依赖性扩张）以及舌下含服硝酸甘油后（一种非内皮依赖性扩张剂）测量肱动脉直径。
年轻中国人（平均±标准差8.3±2.5%）、年轻白人（7.9±2.0%）和老年中国人（6.8±2.9%）的内皮依赖性扩张相似，但老年白人的内皮依赖性扩张明显受损（1.8±2.5%，方差分析p<0.001）。多变量分析显示，年龄较大与白人受试者内皮依赖性扩张受损相关（p<0.001）（独立于血清胆固醇、性别和血管大小的影响），而在中国人中则无此关联（p = 0.83）。硝酸甘油诱导的扩张在两个种族群体中均未随年龄增长而有显著差异。
健康的年轻中国成年人和白人成年人的动脉内皮依赖性扩张相似。然而，随着年龄增长，中国受试者内皮功能受损的易感性较低。
