Fisher K A, Ahuja S, Luger A, Spargo B H, Lindheimer M D
Am J Obstet Gynecol. 1977 Nov 15;129(6):643-6. doi: 10.1016/0002-9378(77)90646-9.
During a retrospective study of 100 patients who underwent renal biopsy because of pregnancy complicated by hypertension, we found 19 patients whom proteinuria exceeded 5.0 Gm. per 24 hours and an additional eight patients in whom excretion ranged between 3.5 and 5 Gm. per day. Of these 27 patients, 23 had the kidney lesion of pre-eclampsia, and three of them had superimposed hypertensive changes in the vasculature. The remaining four had other renal diseases. We located and re-examined 10 of the 23 pre-eclamptic women, 12 to 104 (mean, 36) months after delivery. Serum creatinine levels were normal in all but one, who was discovered to have polycystic kidney disease. During the same time period, we located the records of six women who had heavy proteinuria during gestation but were normotensive. Thus, at our institution, pre-eclampsia is the most common cause of the nephrotic syndrome in pregnancy. The frequency of nephrotic proteinuria in pre-eclampsia appears higher than previously suspected, but, despite this fact, recovery was complete in most instances.
在一项对100例因妊娠合并高血压而行肾活检的患者的回顾性研究中，我们发现19例患者24小时蛋白尿超过5.0克，另有8例患者每日蛋白尿排泄量在3.5至5克之间。在这27例患者中，23例患有先兆子痫的肾脏病变，其中3例血管系统有叠加的高血压变化。其余4例患有其他肾脏疾病。我们对23例先兆子痫女性中的10例进行了产后12至104个月（平均36个月）的定位和复查。除1例被发现患有多囊肾病外，其余所有患者的血清肌酐水平均正常。在同一时期，我们找到了6例妊娠期蛋白尿严重但血压正常的女性的记录。因此，在我们机构，先兆子痫是妊娠肾病综合征最常见的原因。先兆子痫中肾病性蛋白尿的发生率似乎比以前怀疑的要高，但是，尽管如此，大多数情况下恢复是完全的。
