Goodyer A V, Wong B Y
Am J Physiol. 1977 Nov;233(5):H555-61. doi: 10.1152/ajpheart.1977.233.5.H555.
Strength-interval curves, relating an index of the contractile vigor of premature beats to their coupling intervals, were elicited in anesthetized, open-chest dogs prepared for atrial or ventricular pacing and the high-fidelity measurement of left ventricular pressure. During inotropic interventions, changes of the curves were evaluated in terms of the parameters (slopes and intercepts) of their straight lines of best fit. These parameters were altered by isoproterenol, propranolol, and heart rate, and were correlated closely with paired values of isovolumic Vmax (of driven beats). The strength-interval curves were reproducible and were not affected by large changes of venous return or arterial blood pressure. These results provide a basis for the use of strength-interval curves for the evaluation of ventricular contractile state, using fluid-filled catheters for the measurement of left ventricular pressure.
在为心房或心室起搏以及左心室压力的高保真测量而制备的麻醉开胸犬中，绘制了将早搏的收缩活力指数与其联律间期相关联的强度 - 间期曲线。在进行变力干预期间，根据其最佳拟合直线的参数（斜率和截距）评估曲线的变化。这些参数会因异丙肾上腺素、普萘洛尔和心率而改变，并且与驱动搏动的等容Vmax的配对值密切相关。强度 - 间期曲线具有可重复性，不受静脉回流或动脉血压大幅变化的影响。这些结果为使用强度 - 间期曲线评估心室收缩状态提供了基础，该评估使用充液导管测量左心室压力。
