通过基因转移到家畜中来生成生物学模型。
Generating biological models through gene transfer to domestic animals.
作者信息
Houdebine L M
机构信息
Unité de différenciation cellulaire, Inra, Jouy-en-Josas, France.
出版信息
Vet Res. 1997 May-Jun;28(3):201-5.
PMID:9208440
Abstract
Transgenic domestic animals remain infrequently used as models for biochemical, biomedical or pharmaceutical studies. The difficulty in obtaining these animals and the cost of their maintenance explains this situation. This review briefly summarizes the different techniques of gene transfer, targeted or not, and also the techniques for constructing vectors for transgene expression. A few examples of domestic animal models are also reported.
摘要
转基因家畜很少被用作生化、生物医学或制药研究的模型。获取这些动物的困难以及饲养成本解释了这种情况。本文简要总结了有无靶向性的不同基因转移技术，以及构建转基因表达载体的技术。还报道了一些家畜模型的例子。
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