Li X, Wu J, Liu J
Shanghai Institute of Biological Products.
Zhonghua Yu Fang Yi Xue Za Zhi. 1996 May;30(3):151-3.
In order to evaluate immune persistence of plasma-derived hepatitis B vaccine (HBV), 344 children in a primary school were followed up for seven years by detection of serum HBsAg, anti-HBc and anti-HBs with radioimmunoassay (RIA) using Abbott reagent kits. In the seventh year after three-dose HBV immunization, level of anti-HBs in 55.4%-75.0% of the vaccinee was greater than 10 IU/L, with a geometric mean titer (GMT) of 20.9-65.3 IU/L. The higher the level of anti-HBs, the longer the duration of its decrease from more than to less than 10 IU/L. Seven years after immunization, 66 children with varied serum levels of anti-HBs were received a fourth dose of 10 micrograms HBV, and one month after revaccination, their levels of anti-HBs increased by 6.3-57.7 times. It suggests revaccination of HBV is not necessary for children vaccinated within seven years.
为评估血浆源性乙肝疫苗（HBV）的免疫持久性，采用雅培试剂盒通过放射免疫分析法（RIA）检测血清HBsAg、抗-HBc和抗-HBs，对一所小学的344名儿童进行了7年的随访。在3剂HBV免疫接种后的第7年，55.4%-75.0%的接种者抗-HBs水平大于10 IU/L，几何平均滴度（GMT）为20.9-65.3 IU/L。抗-HBs水平越高，其从大于10 IU/L降至小于10 IU/L的持续时间越长。免疫接种7年后，对66名抗-HBs血清水平各异的儿童接种了第4剂10微克的HBV，再次接种1个月后，他们的抗-HBs水平升高了6.3-57.7倍。这表明对于7年内接种过疫苗的儿童，无需再次接种HBV。
