Hall T J, Cooper M, Hughes R G, Levin B, Skinner D B, Moossa A R
Am J Surg. 1977 Nov;134(5):544-8. doi: 10.1016/0002-9610(77)90430-5.
The clinical, surgical, and pathologic findings in a five year prospective study of 192 patients referred with a high probability of pancreatic cancer are reported. We have defined the requirements of any pancreatic imaging procedure as its ability to distinguish a normal pancreas from pancreatic cancer or chronic pancreatitis and the capability of detecting tumors less than 5 cm in diameter. There was a 47 percent incidence of pancreatic disease (27 percent pancreatic cancer and 20 percent chronic pancreatitis). Prospective radionuclide imaging as routinely performed was found to be of little clinical value in this patient population; it was neither specific nor sensitive to pancreatic cancer or chronic pancreatitis. Preliminary data with longitudinal multiplane emission tomography show an improved diagnostic accuracy and the ability to detect resectable tumors, but its efficacy needs to be prospectively compared with other screening tests on a carefully defined patient population.
报告了对192例极有可能患有胰腺癌而前来就诊的患者进行的为期五年的前瞻性研究中的临床、手术及病理检查结果。我们将任何胰腺成像检查的要求定义为其区分正常胰腺与胰腺癌或慢性胰腺炎的能力，以及检测直径小于5厘米肿瘤的能力。胰腺疾病的发病率为47%（27%为胰腺癌，20%为慢性胰腺炎）。发现常规进行的前瞻性放射性核素成像在该患者群体中临床价值不大；它对胰腺癌或慢性胰腺炎既不具有特异性也不具有敏感性。纵向多平面发射断层扫描的初步数据显示诊断准确性有所提高，且具备检测可切除肿瘤的能力，但其疗效需要在精心定义的患者群体中与其他筛查测试进行前瞻性比较。
