Kimura S, Ogawa T, Hara S, Yoshimoto H, Abe I
Department of Ophthalmology, Hirosaki University School of Medicine, Aomori-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1997 Jun;101(6):492-7.
Outbreak sites of newly formed blood vessels (NFVs) in proliferative diabetic retinopathy (PDR) were analyzed geometrically. A montage was made of fluorescein fundus angiography photographs of 109 eyes and applied to a two dimensional x-y plane in which the center of the optic disc was taken as the origin. Thus each NFV acquired a coordinate value (x, y). After a coordinate transformation of this x-y plane designed to correct the parafoveal distortion of vascular distribution, a polar coordinate value (r, theta) of the NFV was calculated. The frequencies of NFVs were analyzed statistically relating to both theta, which is the angle around the origin, and r, which is the distance from the origin. The average theta was 2.74 +/- 1.72 (mean +/- standard deviation) radians and the outbreak frequency of NFVs showed a homogeneous distribution which was not influenced by any difference in theta. As for r, the frequency corrected as a truncated distribution at r = 0 showed a normal distribution with an average of 1.45 +/- 0.8. The outbreak of NFVs in PDR is a phenomenon in which accidental elements are strongly concerned and it is thought to be difficult to predict the site at early stage of retinopathy.
对增殖性糖尿病视网膜病变（PDR）中新形成血管（NFV）的爆发部位进行了几何学分析。制作了109只眼睛的荧光素眼底血管造影照片的蒙太奇，并应用于以视盘中心为原点的二维x-y平面。因此，每个NFV都获得了一个坐标值（x，y）。在对该x-y平面进行坐标变换以校正血管分布的黄斑旁扭曲后，计算了NFV的极坐标值（r，θ）。对NFV的频率进行了统计分析，涉及到围绕原点的角度θ和距原点的距离r。平均θ为2.74 +/- 1.72（平均值 +/- 标准差）弧度，NFV的爆发频率呈均匀分布，不受θ差异的影响。至于r，在r = 0处校正为截断分布的频率呈正态分布，平均值为1.45 +/- 0.8。PDR中NFV的爆发是一种与偶然因素密切相关的现象，并且认为在视网膜病变的早期阶段很难预测其部位。
