Ding M, Wong J L, Rogers N E, Ignarro L J, Voskuhl R R
Department of Neurology, School of Medicine, University of California, Los Angeles 90095, USA.
J Neuroimmunol. 1997 Jul;77(1):99-106. doi: 10.1016/s0165-5728(97)00065-9.
We identified gender related differences of inducible nitric oxide synthase (iNOS) expression and NO production in mice with experimental autoimmune encephalomyelitis (EAE). When myelin basic protein-specific T-lymphocytes derived from female mice were transferred, the female recipients developed more severe EAE and expressed higher levels of iNOS and NO than male recipients. When the T-lymphocytes derived from males were transferred, severe EAE was induced in neither female or male recipients and neither iNOS nor NO were detectable. These data show an association between No production and EAE severity, suggesting a possible role of NO in the pathogenesis of EAE.
我们在患有实验性自身免疫性脑脊髓炎（EAE）的小鼠中确定了诱导型一氧化氮合酶（iNOS）表达和一氧化氮（NO）产生的性别相关差异。当转移来自雌性小鼠的髓鞘碱性蛋白特异性T淋巴细胞时，雌性受体发生的EAE更严重，并且iNOS和NO的表达水平高于雄性受体。当转移来自雄性的T淋巴细胞时，雌性或雄性受体均未诱导出严重的EAE，并且未检测到iNOS和NO。这些数据表明NO产生与EAE严重程度之间存在关联，提示NO在EAE发病机制中可能起作用。
