染色体易位与白血病：LMO2在T细胞急性白血病、转录及红细胞生成中的作用
Chromosomal translocations and leukaemia: a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis.
作者信息
Rabbitts T H, Axelson H, Forster A, Grutz G, Lavenir I, Larson R, Osada H, Valge-Archer V, Wadman I, Warren A
机构信息
MRC Laboratory of Molecular Biology, Cambridge, UK.
出版信息
Leukemia. 1997 Apr;11 Suppl 3:271-2.
The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.
与T细胞急性白血病相关的LMO2基因已被用作一个基因的例子，该基因在染色体易位后通过与T细胞受体基因结合而被激活。该基因编码一种LIM蛋白，该蛋白参与蛋白质相互作用，在正常造血过程中对红系发育是必需的。已证明LMO2异常表达时会导致肿瘤，并且能够与TAL1异源二聚化以促进肿瘤发展。
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