Crespi F, Corsi M, England T, Ratti E, Trist D G, Gaviraghi G
Glaxo Wellcome S.p.A. Medicines Research Centre, Verona, Italy.
Alcohol. 1997 Jul-Aug;14(4):327-32. doi: 10.1016/s0741-8329(96)00179-6.
Naive adult male Wistar rats free to choose between water or 10% ethanol (v/v) spontaneously became water-preferring (WP) rats, as they drank mainly water (approximately 35 ml per day), or alcohol-drinking (ED) rats, as they also drank a significant amount of ethanol (approximately 14 ml per day). The selective CCKA receptor antagonist L-364,718 at doses selective for the CCKA receptor (5 micrograms/kg, IP) halved the consumption of alcohol of the ED rats without modifying their total liquid in-take. In contrast, the CCKB antagonists L-365,260 or GV150013 were without effect when used at doses selective for the CCKB receptor. These data indicate that the CCK system could be involved in the modulation of alcohol intake. In particular, they suggest that CCKA receptors could play a role in the ethanol preference.
成年雄性Wistar大鼠可在水和10%乙醇（体积/体积）之间自由选择，它们会自发地成为偏好水的（WP）大鼠，因为它们主要饮水（每天约35毫升），或者成为饮酒的（ED）大鼠，因为它们也会饮用大量乙醇（每天约14毫升）。选择性CCKA受体拮抗剂L-364,718以对CCKA受体有选择性的剂量（5微克/千克，腹腔注射）使ED大鼠的乙醇消耗量减半，而不改变它们的总液体摄入量。相比之下，CCKB拮抗剂L-365,260或GV150013以对CCKB受体有选择性的剂量使用时则没有效果。这些数据表明CCK系统可能参与了酒精摄入量的调节。特别是，它们表明CCKA受体可能在乙醇偏好中起作用。
