Quillard M, Renouf S, Husson A, Meisse D, Lavoinne A
Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle (GBPDN), Institut Fédératif de Recherches Multidisciplinaires sur les Peptides n. 23 (IFRMP), UFR Médecine-Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Biochimie. 1997 Feb-Mar;79(2-3):125-8. doi: 10.1016/s0300-9084(97)81503-9.
The repertoire of the actions of specific amino acids on gene expression is relatively limited in mammalian cells. Glutamine constitutes the most studied amino acid and recent works intended to demonstrate its mechanism of action on two genes: the beta-actin and the phosphoenolpyruvate carboxykinase genes. From these studies, it appears that glutamine may regulate gene expression by, at least, two different mechanisms: one through the glutamine-induced cell swelling, and another through its intracellular metabolism. The involvement of phosphatidylinositol 3-kinase in the signaling pathway triggered by cell swelling is discussed.
在哺乳动物细胞中，特定氨基酸对基因表达的作用种类相对有限。谷氨酰胺是研究最多的氨基酸，最近的研究旨在阐明其对两个基因——β-肌动蛋白基因和磷酸烯醇式丙酮酸羧激酶基因的作用机制。从这些研究来看，谷氨酰胺似乎至少可通过两种不同机制调节基因表达：一种是通过谷氨酰胺诱导的细胞肿胀，另一种是通过其细胞内代谢。文中还讨论了磷脂酰肌醇3激酶在细胞肿胀触发的信号通路中的作用。
