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原发性和转移性恶性黑色素瘤患者对单核细胞趋化蛋白1的人单核细胞趋化反应显著降低。

Significant reduction of human monocyte chemotactic response to monocyte-chemotactic protein 1 in patients with primary and metastatic malignant melanoma.

作者信息

Müller R, Zheng M, Mrowietz U

机构信息

Dept of Dermatology, University of Kiel, Germany.

出版信息

Exp Dermatol. 1997 Apr;6(2):81-6. doi: 10.1111/j.1600-0625.1997.tb00151.x.

Abstract

The recruitment of leukocytes from the peripheral blood is a key event for the development and composition of the inflammatory infiltrate in solid tumors and tumor metastases like malignant melanoma. Tumor-infiltrating lymphocytes (TIL) and tumor-associated macrophages (TAM) are thought to play a crucial rôle in tumor immunosurveillance. In malignant melanoma expression and secretion of monocyte-chemotactic protein 1 (MCP-1) have been demonstrated. MCP-1 serves as an attractant for monocytes and activated T-cells. In this study we addressed the question whether circulating monocytes show altered chemotaxis to MCP-1. Therefore the chemotactic responsiveness of monocytes towards MCP-1 was investigated in patients with primary and metastatic melanoma and compared to patients with basal cell carcinoma and healthy persons. The results show that monocytes from melanoma patients showed a significantly decreased chemotactic migration towards MCP-1 while chemotaxis to the stimulus N-formyl-methionyl-leucyl-phenylalanine (FMLP) remained normal. Patients with basal cell carcinoma showed normal monocyte chemotaxis to all stimuli tested. In primary melanoma, there was no relation of the number of TAM or TIL to the decreased chemotaxis of circulating monocytes to MCP-1. From these data it can be concluded that circulating monocytes from patients with primary and metastatic melanoma show a MCP-1-specific decrease in chemotactic migration. This may be due to deactivation or modulation of the MCP-1-receptor expression on these cells.

摘要

从外周血募集白细胞是实体瘤和肿瘤转移(如恶性黑色素瘤)中炎症浸润发展和组成的关键事件。肿瘤浸润淋巴细胞(TIL)和肿瘤相关巨噬细胞(TAM)被认为在肿瘤免疫监视中起关键作用。在恶性黑色素瘤中,已证实单核细胞趋化蛋白1(MCP-1)的表达和分泌。MCP-1作为单核细胞和活化T细胞的趋化剂。在本研究中,我们探讨了循环单核细胞对MCP-1的趋化性是否改变。因此,研究了原发性和转移性黑色素瘤患者单核细胞对MCP-1的趋化反应性,并与基底细胞癌患者和健康人进行了比较。结果表明,黑色素瘤患者的单核细胞对MCP-1的趋化迁移显著降低,而对刺激物N-甲酰甲硫氨酰亮氨酰苯丙氨酸(FMLP)的趋化性保持正常。基底细胞癌患者的单核细胞对所有测试刺激物的趋化性均正常。在原发性黑色素瘤中,TAM或TIL的数量与循环单核细胞对MCP-1趋化性降低无关。从这些数据可以得出结论,原发性和转移性黑色素瘤患者的循环单核细胞对MCP-1的趋化迁移表现出特异性降低。这可能是由于这些细胞上MCP-1受体表达的失活或调节。

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