Zheng M, Sun G, Cai S, Mueller R, Mrowietz U
Department of Dermatology, Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009, China.
Chin Med J (Engl). 1999 Jun;112(6):493-6.
To address whether circulating T-cells from the patients with primary and metastatic malignant melanoma show altered chemotaxis to monocyte-chemotactic protein 1 (MCP-1) and its relation to tumor infiltrating lymphocyte (TIL) and metastasis.
Chemotactic response of T-cells towards MCP-1 and immuno-histochemistry study of TIL and tumor-associated-macrophages (TAM) were investigated in patients with primary and metastatic melanoma compared to patients with basal cell carcinoma and healthy persons.
T-cells from patients with primary and metastatic melanoma showed a significantly decreased chemotactic migration towards MCP-1 and T-cells from patients with basal cell carcinoma showed normal chemotactic response. Immuno-histochemistry study showed that there was no correlation between the number of TIL and the decreased chemotaxis of circulating T-cells to MCP-1 in patients with primary melanoma.
Circulating T-cells from patients with primary and metastatic melanoma showed a MCP-1-specific decrease in chemotactic migration. This may be due to abnormal expression or modulation of MCP-1-receptor expression on these cells.
探讨原发性和转移性恶性黑色素瘤患者循环T细胞对单核细胞趋化蛋白1（MCP-1）的趋化性是否改变，以及其与肿瘤浸润淋巴细胞（TIL）和转移的关系。
与基底细胞癌患者和健康人相比，研究原发性和转移性黑色素瘤患者T细胞对MCP-1的趋化反应以及TIL和肿瘤相关巨噬细胞（TAM）的免疫组织化学研究。
原发性和转移性黑色素瘤患者的T细胞对MCP-1的趋化迁移显著降低，基底细胞癌患者的T细胞趋化反应正常。免疫组织化学研究表明，原发性黑色素瘤患者TIL数量与循环T细胞对MCP-1趋化性降低之间无相关性。
原发性和转移性黑色素瘤患者的循环T细胞对MCP-1的趋化迁移表现出特异性降低。这可能是由于这些细胞上MCP-1受体表达异常或调节所致。
