Rathi V M, Krishnamachary M, Gupta S
Sight Savers Cornea Training Centre, L.V. Prasad Eye Institute, Hyderabad, India.
J Cataract Refract Surg. 1997 May;23(4):562-4. doi: 10.1016/s0886-3350(97)80214-3.
To assess the incidence and risk factors for developing cataract after penetrating keratoplasty (PKP).
L.V. Prasad Eye Institute, Hyderabad, India.
This retrospective analysis of 251 phakic patients who had PKP between 1987 and 1994 assessed the incidence of and risk factors for cataract formation. Patients were assigned to one of two groups: Group 1 (n = 96), patients with keratoconus and corneal dystrophy; Group 2 (n = 88), patients with corneal scar and adherent leucoma. Preoperative, intraoperative, and postoperative lens details were noted. Data on intraoperative iris procedures (excess manipulation, pupilloplasty, synechiolysis, peripheral iridectomy) and postoperative topical steroid usage were assessed.
Sixty-seven patients were excluded because of incomplete lens status data. Of the remaining 184 patients, 45 (24.45%) developed cataract. Most cataracts (n = 31) developed within the first year of surgery. The incidence of cataract was significantly higher in Group 2 (n = 29) than in Group 1 (n = 16) (P = .0102). There was no significant between-group difference in mean steroid dose (P = .7064); however, the mean dose was significantly higher in eyes with cataracts (563 +/- 234 units) than in those without (479 +/- 127 units) (P = .0352). In Group 2, 9 of 20 patients who had synechiolysis, 1 of 3 who had pupilloplasty, and 2 of 5 who had peripheral iridectomy developed cataract. In Group 1, no patient had iris-related procedures.
Excessive steroid use and intraoperative iris manipulations are major risk factors for cataract formation after PKP.
评估穿透性角膜移植术（PKP）后白内障发生的发生率及危险因素。
印度海得拉巴市的L.V.普拉萨德眼科研究所。
对1987年至1994年间接受PKP手术的251例有晶状体患者进行回顾性分析，评估白内障形成的发生率及危险因素。患者被分为两组：第1组（n = 96），圆锥角膜和角膜营养不良患者；第2组（n = 88），角膜瘢痕和粘连性角膜白斑患者。记录术前、术中和术后晶状体的详细情况。评估术中虹膜操作（过度操作、瞳孔成形术、虹膜粘连分离术、周边虹膜切除术）及术后局部使用类固醇的数据。
67例患者因晶状体状态数据不完整被排除。在其余184例患者中，45例（24.45%）发生了白内障。大多数白内障（n = 31）在术后第一年内发生。第2组（n = 29）白内障的发生率显著高于第1组（n = 16）（P = 0.0102）。两组间平均类固醇剂量无显著差异（P = 0.7064）；然而，有白内障的眼平均剂量（563±234单位）显著高于无白内障的眼（479±127单位）（P = 0.
