Ito S
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1997 Apr;181(4):411-29. doi: 10.1620/tjem.181.411.
The kidney plays an important role in the pathophysiology of hypertension. Recent studies suggest that glomerular hemodynamics may be critically involved not only in the pathogenesis of hypertension but also in the mode of progression of renal dysfunction. The juxtaglomerular apparatus (JGA), consisting of the glomerular afferent and efferent arterioles and the specialized tubular epithelial cells called the macula densa, plays a central role in the regulation of glomerular hemodynamics and renin release. This article reviews the mechanism by which the JGA controls renin release and glomerular hemodynamics as well as its relevance in the pathogenesis, pathophysiology and treatment of hypertension.
肾脏在高血压的病理生理学中起着重要作用。最近的研究表明，肾小球血流动力学不仅可能在高血压的发病机制中起关键作用，而且在肾功能障碍的进展模式中也起关键作用。肾小球旁器（JGA）由肾小球入球小动脉和出球小动脉以及称为致密斑的特殊肾小管上皮细胞组成，在肾小球血流动力学调节和肾素释放中起核心作用。本文综述了肾小球旁器控制肾素释放和肾小球血流动力学的机制及其在高血压发病机制、病理生理学和治疗中的相关性。
