Gumbiner B M
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, Box 564, 1275 York Avenue, New York, New York 10021, USA.
Curr Biol. 1997 Jul 1;7(7):R443-6. doi: 10.1016/s0960-9822(06)00214-4.
A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.
一种最初因其与钙黏蛋白细胞黏附分子相关联而被鉴定出的蛋白质——β-连环蛋白，已被认为与致癌作用有关。在许多不同类型的癌症中，通过β-连环蛋白的信号传导要么因β-连环蛋白的直接突变而上调，要么因APC肿瘤抑制蛋白的负调控丧失而上调。
