Shah D T, Walker E M, Jones M M, Singh P K, Larsen B
Department of Pathology, Marshall University School of Medicine, Huntington, WV 25705, USA.
Ann Clin Lab Sci. 1997 Jul-Aug;27(4):282-6.
Thirty clinical isolates of Candida albicans and 10 other Candida species were tested for susceptibility to 6 substituted dithiocarbamates and one dimercaptosuccinate. Dimethyldithiocarbamate, sodium pyrrolidine dithiocarbamate, and sodium diethyldithiocarbamate showed dose-dependent antifungal activity which was partially reversed by the addition of zinc, copper, or iron sulfate with greatest reversal at 2:1 metal to dithiocarbamate molar ratio. Anaerobiosis also interfered with dithiocarbamate antifungal activity.
对30株白色念珠菌临床分离株和10株其他念珠菌进行了6种取代二硫代氨基甲酸盐和1种二巯基琥珀酸盐的药敏试验。二甲基二硫代氨基甲酸盐、吡咯烷二硫代氨基甲酸钠和二乙基二硫代氨基甲酸钠表现出剂量依赖性抗真菌活性，添加硫酸锌、硫酸铜或硫酸铁可部分逆转这种活性，在金属与二硫代氨基甲酸盐摩尔比为2:1时逆转作用最大。厌氧环境也会干扰二硫代氨基甲酸盐的抗真菌活性。
