Kachi S, Terada M, Hashimoto H
Department of Parasitology, Hamamatsu University School of Medicine, Japan.
Parasitol Res. 1997;83(6):578-82. doi: 10.1007/s004360050301.
Our previous in vivo studies on angiostrongyliasis showed that PF1022A had stronger killing effects against female adults than against males. No killing effects were observed against young adult worms in the central nervous system. To characterize the former in vivo action of PF1022A, in vitro effects of PF1022A on the motility of Angiostrongylus cantonensis were studied directly. Few differences in the efficacy were observed between male and female worms, but dose- and time-dependent inhibition was observed in adults treated with PF1022A at 10(-7)-10(-11) g/ml. PF1022A was slightly less effect we against young-adult worms than against adult worms. Minor effects of PF1022A were observed on the third-stage larvae. These results suggest that selectivity against adult females in vivo could be attributable to non-neuropharmacological mechanisms and that PF1022A does not pass through the blood-brain barrier in host animals.
我们之前关于广州管圆线虫病的体内研究表明，PF1022A对雌虫的杀灭作用比对雄虫更强。未观察到对中枢神经系统中年轻成虫的杀灭作用。为了表征PF1022A之前的体内作用，直接研究了PF1022A对广州管圆线虫运动性的体外影响。在雄虫和雌虫之间观察到的药效差异不大，但在用10(-7)-10(-11) g/ml的PF1022A处理的成虫中观察到了剂量和时间依赖性抑制。PF1022A对年轻成虫的作用略小于对成虫的作用。观察到PF1022A对第三期幼虫有轻微影响。这些结果表明，体内对成年雌虫的选择性可能归因于非神经药理学机制，并且PF1022A在宿主动物中不会穿过血脑屏障。
