Ackerman J, Gilbert-Barness E
Department of Pathology and Laboratory Medicine, University of South Florida, Tampa, USA.
Pediatr Pathol Lab Med. 1997 Jul-Aug;17(4):577-86.
Breast cancer is rare in adolescent females. Breast cancer metastatic to the products of conception is equally uncommon. We describe a 15-year-old girl who at 30 weeks of gestation was diagnosed with metastatic adenocarcinoma of probable breast origin. The placenta showed extensive intervillous disease. Metastatic disease within the intervillous space indicates hematogenous dissemination of cancer and a poor prognosis for the mother. The infant is almost always free of maternal disease unless there is villous invasion. Hormonal changes or immunotolerance by the mother may be involved in the pathogenesis. All placentas in which maternal malignancy is known or suspected should be examined grossly and microscopically.
乳腺癌在青春期女性中较为罕见。转移至妊娠产物的乳腺癌同样不常见。我们描述了一名15岁女孩，她在妊娠30周时被诊断为可能源于乳腺的转移性腺癌。胎盘显示有广泛的绒毛间隙病变。绒毛间隙内的转移病变提示癌症的血行播散，且母亲预后不良。除非有绒毛侵犯，婴儿几乎总是不受母体疾病影响。发病机制可能涉及母亲的激素变化或免疫耐受。所有已知或怀疑有母体恶性肿瘤的胎盘均应进行大体和显微镜检查。
