Massé R, Quillard A, Héry B, Toudic L, Le Her G
Ann Dermatol Venereol. 1977 Jun-Jul;104(6-7):441-5.
Acrokerato-elastoidosis described by Costa is characterized by numerous little keratotic points and translucent horny wheals on the dorsal aspect of hands and (or) feet. The ultrastructural study shows lesions of the elastic tissue which is very rarefied with an abnormal structure, but also demonstrates alterations of the fibroblasts that contain dense granules at the periphery of their cytoplasm without elastic extracellular fibers, suggesting a trouble in the secretion or the excretion of the elastic material.
科斯塔所描述的肢端角化性弹性组织病的特征是，在手背和（或）足背出现众多微小的角化性丘疹和半透明角质性风团。超微结构研究显示弹性组织病变，弹性组织非常稀少且结构异常，同时还表明成纤维细胞发生改变，这些成纤维细胞在其细胞质周边含有致密颗粒，且无细胞外弹性纤维，提示弹性物质的分泌或排泄存在问题。
