Chase C, Pinkham R, Swift M
Ann Hum Genet. 1977 Jul;41(1):123-32. doi: 10.1111/j.1469-1809.1977.tb01970.x.
A maximum-likelihood method has been used previously to estimate, from family studies, the relative risk of common disorders for heterozygous carriers of genes for certain autosomal recessive syndromes. In this paper statistical significance of relative risk estimates was evaluated using critical values from computer-generated sampling distributions of the test statistic. In several practical cases a significance test based on the computer-generated distribution was more conservative than a test which assumed normality for the sampling distribution.
此前已采用最大似然法，根据家系研究来估计某些常染色体隐性综合征基因的杂合子携带者患常见疾病的相对风险。在本文中，利用检验统计量的计算机生成抽样分布的临界值，评估了相对风险估计值的统计学显著性。在几个实际案例中，基于计算机生成分布的显著性检验比假定抽样分布呈正态性的检验更为保守。
