Szalai A J, Agrawal A, Greenhough T J, Volanakis J E
Department of Medicine, University of Alabama at Birmingham 35294, USA.
Immunol Res. 1997;16(2):127-36. doi: 10.1007/BF02786357.
Over the past few years substantial insight was gained into the biology and biochemistry of human C-reactive protein (CRP). X-ray crystallography in conjunction with mutational analyses, generated the three-dimensional structure of the protein and indicated the topology and structure of ligand-binding sites. Using human CRP transgenic mice infected with Streptococcus pneumoniae, we obtained data that clearly established CRP as an important host defense molecule. Studies using the same mice revealed a previously unknown testosterone-dependence of constitutive expression of human CRP. In this article we provide a brief overview of these recent findings.
在过去几年中，人们对人类C反应蛋白（CRP）的生物学和生物化学有了深入了解。X射线晶体学结合突变分析，得出了该蛋白的三维结构，并揭示了配体结合位点的拓扑结构和结构。通过使用感染肺炎链球菌的人类CRP转基因小鼠，我们获得的数据明确证实CRP是一种重要的宿主防御分子。对这些小鼠的研究还揭示了人类CRP组成型表达以前未知的睾酮依赖性。在本文中，我们简要概述了这些最新发现。
